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KMID : 0614020090240010049
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Journal of Pharmaceutical Sciences (C.N.U.)
2009 Volume.24 No. 1 p.49 ~ p.57
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Lupane Triterpenoids from Acanthopannax Species
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Nguyen Xuan-Nhiem
Nguyen Huu-Tung
Tai Bui-Tuu
Kim Young-Ho
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Abstract
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Acanthopanax species (Araliaceae) are widely distributed in Korea, Japan, China, and the far-eastern region of Russia. The barks and small branches of these species have traditionally been used as a tonic and a sedative as well as in the treatment of rheumatism and diabetes. Their chemical components and pharmaco-logical activities were studied by several groups worldwide. Lignans, phenylpropanoids, coumarins, flavonoids, terpenoids and polyacetylenes have been isolated from Acanthopanax species and have been shown to have various activities such as anti-bacterial, anti-cancer, anti-gout, anti-hepatitis, anti-hyperglycemic, anti-inflammatory, anti-oxidant, anti-pyretic, anti-xanthine oxidase, choleretic, hemostatic, hypocholesterolemic, immunostimulatory and radioprotectant effects, etc. One the major components of these species is lupane triterpenoids. Herein, we review the islolated lupane type triterpenoids from Acanthopanax species ahd their ¹³C-NMR chemical shifts related with functional groups of aglycones.
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KEYWORD
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Acanthopanax, Araliaceae, Lupane triterpenoid
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